Propolis is plant resin collected by the bees to serve various critical functions in the hive, such as providing physical protection, maintaining hive homeostasis, acting as an antimicrobial and immune-modulator substance, and so on. More importantly, propolis has a wide range of therapeutic and health benefits for humans ranging from antimicrobial, anti-inflammation, antioxidant, and anticancer. This talk will present the therapeutic benefits of propolis in metabolic syndrome and its chronic diseases (cardiovascular diseases, type 2 diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, and Alzheimer’s disease), with particular emphasis on human clinical trials and the common denominators on how propolis works therapeutically on those disorders. The talk will also present the research that has been carried out by our group investigating the propolis of Indonesian stingless bees.